A Association of Helicobacter Pylori with Presence of Myocardial Infarction in Iran Systematic Review and Meta-Analysis

Abstract

BACKGROUND: Over the past decade, cardiovascular diseaseshave been recognized as the leading cause of mortality worldwide.Myocardial infarction (MI) is one of the most prevalent types ofcardiovascular diseases that is caused by the closure of coronaryarteries and ischemic heart muscle. Numerous studies haveanalyzed the role of H. pylori as a possible risk factor for coronaryartery diseases, in most of which the role of infection in coronaryartery disease is not statistically significant.METHODS: These contradictory findings made us conduct asystematic review to analyze all relevant studies in Iran through ameta-analysis and report a comprehensive and integrated result.All published studies from September 2000 until September2016were considered. Using reliable Latin databases like PubMed, Google Scholar,Google search, Scopus, Science Direct and Persian databases likeSID, Irandoc, Iran Mede and Magiran. After quality control, thesestudies were entered into a meta-analysis by using the randomeffects model. After evaluatingthe studies, 11 papers were finally selected and assessed.RESULTS: A total of 2517 participants had been evaluated in thesestudies, including 1253 cases and 1264 controls. Based on theresults of meta-analysis and using random effects model, an overallestimate ofOR Helicobacter Pylori with Presence of Myocardial Infarctionin Iran was OR=2.53 (CI=1.37-4.67).CONCLUSIONS: The results of this review study show that H.pylori are associated with the incidence of MI so that the odds ratioof MI in the patients with helicobacter pylori is twice greater thanthat of the people without H. pylori. Future studies arerecommended to evaluate the mechanisms associated with relationof H. pylori with MI as well as its association with time.